The interview (courtesy of GameTrailers.com) itself is well worth watching as there's plenty of interesting new details about the upcoming video game. However, it's what Brown says at the 0:40 point which really piqued my interest. Before you go any further, beware of MAJOR SPOILERS AHEAD.
"Obviously something really big happened in Manhattan in the movie and after that is where the game is starting actually. You get to see what happens next and you get to interact with the Lizard and Connors in a completely different way."
As the video game is set in the same universe as the film, this seems like confirmation that Curt Connors/The Lizard survives his final battle with Spider-Man in the Marc Webb helmed reboot. While tie-in's such as this one play absolutely no part in influencing what happens in the movies, the fact it takes place following the events of
The Amazing Spider-Man makes it highly unlikely they would resurrect a character who is killed off on the big screen! In the comic books, Peter helps cure Connors and the two end up working together on several different occasions. Whether he'll be incarcerated at the conclusion of the film or will stick around as some sort of mentor (a third option is that the Lizard returns of course!) is unknown as is whether actor Rhys Ifans is signed up to return. Sound off with your thoughts on this potential spoiler in the usual spot.
STARRING:
Andrew Garfield as Peter Parker/Spider-Man
Emma Stone as Gwen Stacy
Rhys Ifans as Curt Connors/The Lizard
Martin Sheen as Uncle Ben
Sally Fields as Aunt May
Denis Leary as George Stacy
RELEASE DATE: July 3rd, 2012.