Directions the NEW take on Spider-Man could take...
His first solo movie will no doubt be quite comedic with Peter being just a kid. I think Mysterio would fit the bill quite well, maybe with Scorpion as a side villain, which would also be a cool way of setting up Mac Gargan for Venom.
For a darker second movie a team-up with Daredevil vs the Kingpin would be awesome but maybe even a team-up with Blade vs Morbius?!? Snipes is talking to Marvel apparently...
I have no doubt that Marvel is going to want to introduce Norman Osborn for a key role in setting up the Thunderbolts and leading to Avengers: Secret Invasion, Dark Reign for after Infinity WAR. Matthew Maconaghy would be a great Norman Osborn!
Also I don't think that Sinister Six is dead by any means and we may still see a Venom spin-off movie and a Maximum Carnage movie eventually.
MCU Spidey:
2016 - Civil WAR
2017 - Spectacular Spider-Man (Mysterio)
2018 - Infinity WAR pt.1
2019 - Infinity WAR pt.2
2019 - Crime & Punishment (Spidey, DareDevil, Black Cat, Kingpin, Punisher, Bullseye)
2020 - Thunderbolts (Introducing Norman Osborn)
2021 - Sinister Six ( Hobgoblin, Doc Ock, Vulture, Kraven, Venom, Mysterio)
2022 - Secret Invasion (Skrulls)
2023 - Dark Reign (Thunderbolts vs Secret Avengers)
2023 - Venom
2024 - Maximum Carnage (Venom, Carnage, Jackal, Kaine, Scarlet Spider, Miles Morales, death of Peter Parker?)
2026 - Spider-Man Returns (Miles)