So this is a total fancast, I know that some of this rights belongs to FOX.
The story is based on post Ultimatum Ultimate Spider-Man, when Johnny Storm and Bobby Drake moves to Peter Parker's house and Aunt May knows Peter's identity.
This is only the first season cast, during this season Peter is an experimented SPidey, at least he has been Spidey for one year, here the Main Villain is Norman Osborn, he's not Green Goblin untill last episodes, he hires some criminals to kill Spidey, some of the characters are based on the 616 version, I saved some villains for a second season. Some of the characters like Harry and Curt Connors are normal, they havent changed to villains.
Main Characters:
Peter Parker/Spider-man - Matthew Knight
Johnny Storm/Human Torch - David Henrie
Bobby Drake/ Ice-Man - Dylan Sprouse
Gwen Stacy - Bridgit Mendler
Mary Jane - Molly Quinn
Kitty Pryde/Shadowcat - Danielle Campbell
Aunt May - Jessica Walter
Harry Osborn - Chris Galya
Norman Osborn - Jack Coleman
Recurring Characters:
Fash Thompson - Alex Ludwing
Randy Robertson - Brandon Smith
Kenny Kong - Joe Massigilll
Curt Connors - Linus Roache
Lizz Allan - Zendaya Coleman
Jessica Drew/Spider-woman - Vanessa Marano
J.J Jameson - Matt Riedy
Robert Robertson - Ruben S. Hudson
Betty Brant - Hayley Kiyoko
Villains:
Shocker - Adam Rodriguez
Sandman - Adrian Pasdar
Doc Ock - Christian Clemenson
Kraven The Hunter - Matthew Fox
Mysterio - Seamus Dever
Bombshell Mother - Jessica Lowndes
Bombshell - Ryan Newman
*Special Guest:
Ben Parker - Patrick Duffy