Jack O'Connell (Starred Up) as Cloud Strife
Alexandra Daddario (True Detective) as Tifa Lockhart
Astrid Berges-Frisbey (I Origins) as Aeris Gainsborough
NOTE: Berges-Frisbey would play Aeris in Crisis Core.
Jacob Lofland (Mud), Mackenzie Foy (Interstellar), and Raffey Cassidy (Tomorrowland) as Young Cloud, Tifa, and Aeris
NOTE: Lofland and Foy would play Cloud and Tifa in Crisis Core. Cassidy would only play Aeris in childhood flashback scenes.
Aaron Taylor Johnson (Nowhere Boy) as Zack Fair
Gackt (Crisis Core: Final Fantasy VII) as Genesis Rhapsodos
Eduardo Noriega (Abre Los Ojos) as Angeal Hewley
Blanca Portillo (Volver) as Gillian Hewley
Harry Lloyd (Game of Thrones) as Lazard Deusericus
Alfred Molina (Boogie Nights) as Professor Hollander
Masanobu Ando (Battle Royale) as Tseng
Dakota Blue-Richards (Skins) as Cissnei
Rinko Kikuchi (The Brothers Bloom) as Elena
Jamie Campbell Bower (The Mortal Instruments: City of Bones) as Reno
Vin Diesel (The Fast and the Furious) as Rude
Liam Cunningham (The Wind that Shakes the Barley) as President Shinra
Cillian Murphy (Sunshine) as Rufus Shinra
Ian McShane (Sexy Beast) as Heidegger
Thora Birch (American Beauty) as Scarlet
Diego Luna (Milk) as Reeve Tuesti/Cait Sith
Lee Arenberg (Pirates of the Caribbean: The Curse of the Black Pearl) as Don Corneo
Octavia Spenser (Snowpiercer) as Elmyra Gainborough
Chad Coleman (The Walking Dead) as Barret Wallace
Daniel Zotvatto (It Follows) as Biggs
Kiersey Clemons (Dope) as Jesse
Jesse Carere (The Stanford Prison Experiment) as Wedge
Kenneth Branagh (Othello) as Cid Highwind
Sami Gayle (Detachment) as Yuffie Kisaragi
Domhnall Gleeson (The Revenant) as Vincent Valentine
Rosamund Pike (Gone Girl) as Shalua Rui
Hailee Steinfeld (Ender's Game) as Shelke Rui
Svetlana Kholchenkova (Tinker Tailor Soldier Spy) as Rosso the Crimson
Tommy Lister (The Dark Knight) as Azul the Cerulean
Caleb Landry Jones (Antiviral) as Nero the Sable
Eddie Redmayne (Jupiter Ascending) as Weiss the Immaculate
Charlotte Gainsbourgh (Melancholia) as Lucrecia Crescent
Burn Gorman (Pacific Rim) as Professor Hojo
Lee Pace (The Fall) as Sephiroth
Cate Blanchett (The Lord of the Rings: Fellowship of the Ring) as Jenova