Shemar Moore as Al Simmons/Spawn.
Laurence R. Harvey as Clown.
Javier Botet as Violator.
Dan Fogler as Detective Sam Burke.
Raphael Sbarge as Twitch Williams.
Dean Cain as Jason Wynn.
William Forsythe as Cogliostro.
Lauren Ambrose as Angela.
Betty Gabriel as Wanda Simmons.
Morris Chestnut as Terry Fitsgerald.
Priah Ferguson as Cyan Fitzgerald.
Terry Crews as Agent Chapel.
Tobin Bell as Malebolgia (Voice).