First and foremost, I want to say how much I enjoyed Spiderman Homecoming. Perfect Spidey film, well written, well casted, and so on and so forth. However, considering how good this movie was, it just gets me hyped for the sequel on July 5th, 2019.
The Title:
I still think Spider-Man: Homecoming is a strange title. Not a bad one, just not one I expected. Obviously the sequel won't be called Homecoming 2, so a title like Spectacular Spider-Man is just perfect in my opinion. It'll represent how much he's improved from before, maybe his life has gotten much better, he's more of a household name now... It just makes sense.
The Story:
It's been reportedly confirmed that the sequel will start "a few minutes" after Avengers 4. Since there's so much uncertainty on what Avengers 4 will exactly be about (for crying out loud, we don't even have an official title yet), there's no telling what exactly happens for Peter Parker as a character. Still, it's safe to say Spider-Man will get a huge boost in confidence after fighting side by side with the Avengers against Thanos or his army. Citizens could look at him more highly, including the Avengers themselves.
Maybe Zendaya's Michelle will be linked to Peter as a love interest. J Jonah Jameson (preferably played by Bryan Cranston) could come into the picture. There's a lot that could be done to make a fresh story. Which also brings me to the next point...
The Other Hero
It's also been said that Spidey will have another hero tag alongside him in the sequel. Which means no more Iron-Man, but also means so much more possibilites. Thinking about it first, it doesn't make much sense to pair a king of a country with a small-time vigilante. It may be a bold choice, but it could work. Say T'Challa comes to Queens to give some speeches at Peter's magnet school. Since T'Challa is a great scientist, it matches up he would go to a specialized science school. Peter could recognize T'Challa, ask him for some help on the current villain he's facing, and from there you could build a "Odd Couple" type friendship.
The Villain:
All in all, these are just some random thoughts I'd like to see for Homecoming 2. Hopefully the sequel will be as good, if not better than the it's predecessor. Time will tell.