The way I think it should go...
I think they should start the apocalypse saga straight form where x3 left off. After Wolvie kills Jean for some stupid reason. Scott should randomly show up a few months later. Having woke up in the woods, not having any idea of what had happened. Than they should bring in madelyne prior, and than bring Jean back, just like the comics. than move into the age of apocalypse. Crappy, but easy fix for everything they screwed up. Aside from that small part. I think they should follow The Myth's story line. Cuz it was amazing. lol. Keep in mind, Shaman has already cast this. I'm just casting people he didn't, aside from Gambit. So, check it out.
First off. The changes I would make.
Rosario Dawson as Storm (Shaman)
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Eric Stoltz as Cyclops.
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Elizabeth Hurley as Jean Grey.
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She needs to be old enough to be Rogue and Nightcrawler's mommy...
Sharon Stone as Mystique.
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Scott Speedman as Angel/Archangel.
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Alan Cummings did an amazing job as nightcrawler. But someone younger is needed for obvious reasons. I chose someone who I think would fit the age, and still look old enough to replace Mr. Cummings in the part.
Justin Long as Nightcrawler.
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Vanessa Ferlito(Myth) as Rogue.
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Shannon Elizabeth as Kitty Pryde.
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Jason Schwartzman as Ahab.
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Vincent Cassell(Myth) as Gambit.
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Nathan Jones as Caliban.
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Collin Chou as Abraham Kieros.
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Thats it. Everything else. I either like what Shaman has done. Or I like the original actor portraying the character.