THE CASTING:
Paul Giamatti as Homero J. Simpson
John Tuturro as Director Seymour Skinner
William H. Macy as Ned Flanders
Benicio del Toro as Snake
John Malkovich as Charles Montgomery Burns
Jacob Bertrand as Bart Simpson
James Earl Jones as Dr. Julius Hibbert
Jack Nicholson as Krusty, the clown
Barry Corbin as Grandpa Simpson
NOTABLE CAMEOS:
Wayne Knight as Peter Griffin
Ben McKenzie as Det. James Gordon
David Duchovny as Fox Mulder
Sarah Michelle Gellar as Buffy Summers