THE CASTING:
Tom Holland as Peter Parker/Spider-Man
Marisa Tomei as Aunt May
Chris Zylka as Eddie Brock
Selena Gómez as Mary Jane Watson
THE SINISTER SIX:
Rainn Wilson as Dr. Otto Octavius/Doctor Octopus (co-leader)
Michael Keaton as Adrian Toomes/Vulture
Tom Hardy as Sergie Kravinoff/Kraven the hunter
Peter Stormare as Aleksei Stysevich/Rhino
Billy Zane as Quentin Beck/Mysterio
Ray Stevenson as Mac Gargan/Scorpion
NOTABLE CAMEOS:
John C. McGinley as Norman Osborn (founder & leader)
Vincent D'Onofrio as Wilson Fisk/Kingpin
Bookem Woodbine as Herman Schulz/Shocker
Mark Gibbon as Flint Marko/Sandman