I will list a few of my favorite Vamps, feel free to add to it, and I would like to hear who you think would win.
Blade: Half breed born by human mother. He's a master at killing his own kind.
Angel: The original Vampire with a soul(in whedonverse). After a feud with gypsies Angelus, the baddest vampire of all time was cursed with a soul, now he too is a master at killing his own kind and other demons.
Spike: The punk rock vampire with a soul. after a chip in his head caused him to no longer to be able to hurt any living soul, he started killing his own kind, which brought him closer to a certain slayer. After trying to rape the woman he loved, the slayer, he went through the demon trails to get his soul back. He's fought and killed two slayers in his time, and is a master at killing his own.
Morbius: The Living Vampire. In an accident while attempting to cure himself of a rare disease, Dr. Morbius gain traits of that of a vampire. He vows only to harm does that are criminals. Morbius and Blade have crossed paths
The winner is up to you, so sound out your opinions below. My personal pick though is Spike, I mean he did take out two slayers, and saved the world from the apocalypse quite a few times.
Remember, this is all about opinions, so try not to get nasty about it.