Logan Lerman as Peter Parker/Spider-Man
Scout Taylor-Compton as Mary Jane Watson
Jesse Eisenberg as Harry Osborn
Evan Rachel Wood as Gwen Stacy
Travis Van Winkle as Flash Thompson
Brittany Snow as Felicia Hardy/Black Cat
Now for the villains. If any of these villains appears in the reboot, here is who should portray them:
Gerard Butler as Kraven the Hunter
Ralph Fiennes as the Vulture
Dominic Purcell as the Scorpion
Roland Kickinger as the Rhino
Dylan Walsh as Mysterio
Gary Oldman as The Lizard
Brian Van Holt as Electro
Michael C. Hall as Hobgoblin
Robert Knepper as Carnage
Stuart Townsend as Morbius
Daniel Craig as Chameleon