Henry Ian Cusick (Desmond Hume) - Banshee / Sean Cassidy
Elizabeth Mitchell (Juliet Burke) - Moira MacTaggert
Kevin Durand (Martin Keamy) - Colossus / Pitor Rasputin
Jeremy Davies (Daniel Faraday) - Nightcrawler / Kurt Wagner
Marsha Thomason (Noami Dorrit) - Storm / Ororo Munroe
Daniel Dae Kim (Jin Kwon) - Sunfire / Shiro Yoshida
M.C. Gainly (Tom Friendly) - Thunderbird / John Proudstar
Josh Holloway (James "Sawyer" Ford) - Wolverine / James "Logan" Howlett
As much as I agree that Josh Holloway would make a sweet Gambit, I do think his character from the show is closer to Wolverine. If you still disagree, watch this clip from Lost
(my personal favourite scene of the series) you will see they are very similar characters.
Sawyer Goes Berserker
Both of them are renegades with hearts of gold, they are both named "James", neither are strangers to taking lives, they both took the names of their father's killers. Not to mention the sometimes awkward love triangles that last throughout both series.
Sam Anderson (Bernard Nadler) - William Stryker
Jorge Garcia (Hugo "Hurley" Reyes - Blob / Frederick J. Dukes
Jeff Fahey (Frank Lapidus) - Black Tom Cassidy