Way back in 1977's Star Wars: A New Hope, Luke Skywalker offered to take "Ben" Kenobi to Anchorhead so he could get a transport to Mos Eisley. It's a place that's never been visited on screen, but in Obi-Wan Kenobi, we will finally see this Tatooine location in live-action for the first time.
Believed to be the planet's main transportation hub, the closest we've come is seeing Tosche Station in The Book of Boba Fett. StarWarsNews.net says the Disney+ series will take us to the "heart" of Anchorhead, and the below shot from the trailer offers our first look at the town's central tower.
Fans have long been curious about Anchorhead, and the site explains that we "might find some similarities between the look of Anchorhead and Los Angeles International Airport, specifically. Since Anchorhead had only previously been referenced, and never actually seen in Star Wars canon, the designers were granted free-range to create the location from scratch."
In related news, Making Star Wars reveals that we'll see Obi-Wan interact with Jawas in the series, but not in a particularly friendly way. Realising he's an outsider on Tatooine, they're constantly stealing his stuff and selling it back to him, and it sounds like this will all play into the frustration the Jedi feels.
So, relatively minor details in the grand scheme of things, but ones that we're definitely intrigued by.