Mysterio
As I stated in 2 previous articles, I think Mysterio should be a villain because of the phsycological challenge he gives Spider-Man. I think it would be very interesting to see on the big screen.
Shocker
I know in one of my articles I stated that he'd be better off with a partner, but after some thought I realized that for a film he can go toe to toe with Spidey physically. Even though he relies too much on his gauntlets, he can still have some what of a fist fight with Spidey.
Scorpion
It would make sense to have Spidey get his photography job in the sequel, and with J. Jonah Jamesons hate for Spider-Man and with Oscorp having a bigger role. It would make sense for them to have J.J hire Mac Gargan to become the Scorpion and have the two go to war.
Chameleon
Chameleon would be (in my opinion) both a phsycologically and physically challenging villain for Spider-Man. Plus with Captain Stacy in The Amazing Spider-Man thinking Spidey is a threat, this would make sense to bring in the Chameleon.
Vulture
I know he was suppose to be the villain in Spider-Man 4, but I think for a second movie he would make for a pretty good villain. He would be able to force Spider-Man to fight him in the air. I don't know about you but I think that would be pretty fricking cool.
There is my top 5, what about you. List yours below.