Garrett Hedlund as Leonardo (voice)
Ian Somerhader as Raphael (voice)
Andrew Garfield as Donatello (voice)
Matt Smith as Michelangelo (voice)
Cary Hiroyuki Tagawa as sensei Splinter (voice)
Lauren Lee Smith as April O'Neil
Taylor Kitsch as Casey Jones
Ken Watanabe as Shredder/Oroku Saki
Maggie Q as Karai
Idris Elba as Dr. Baxter Stockman
Frankie Muniz as Cody Jones O'Neil