Alex Pettyfer as Jonny Quest
Adhir Kalyan or Dav Patel as Hadji Quest-Singh
Damien Lewis as Dr. Benton Quest
George Clooney as Race Bannon
Ken Watanabe as Dr. Zin
CAMEOS:
Evangeline Lilly as Diana Prince/Wonder Woman
Arnold Vosloo as Lex Luthor
Kim Coates as Merlyn the Dark Archer
John Slaterry as King Faraday
Ben Kingsley as Doctor Sivana
Michelle Monaghan as Talia Al Ghul
Cobie Smulders as Selina Kyle/Catwoman
Deborah Ann Woll as Dr. Pamela Isley/Poison Ivy
Michael Copon as Generator Rex