Will Rhino have a major role in the Amazing Spiderman 2 and bring the destruction like he does in the comics?

Sinister six by ASM3????

Giamatti is playing JJJ.
Colm Feore is playing Roderick Kingsley or an FBI guy.
Felicity Jones is Betty Brant.

I hate when people say that a movie has "too many villains". All because of Spider-man 3 and executive meddling.

Check out Batman Begins, please, if you want a semi-recent example. Ra's al Ghul is the head honcho, and is the first to appear - then we get sidetracked to the past and explore the criminal element of Gotham. Joe Chill murders Thomas and Martha Wayne, effectively driving Bruce to becoming Batman, effectively becoming THE villain that Batman will always be hunting down, but never succeeding. Why? Because while still in flashback mode, years later, mob boss Carmine Falcone has Joe Chill killed while leaving court, robbing Bruce of his opportunity to shoot Chill and throw his future away. Now we have TWO established villains, one dead, one still very active, while a third (being the most important) educates Bruce on the ways of becoming a force like Batman.

After learning that he was only being trained in the League of [Shadows] to infiltrate and destroy Gotham, Bruce sabotages their headquarters, fights the apparent "Ra's al Ghul" to the death, and escapes with his very misguided mentor who claims to be Henri Ducard. And while the Ra's al Ghul decoy isn't the big man in charge, Bruce views him as such, and is driven by this revelation of what would have been Gotham's impending destruction, giving Bruce the final bit of motivation to become Batman and protect his city.

We jump back to Gotham in present time and Mr Zsaaz is escaping a prison sentence courtesy of one Jonathan Crane, who would become the Scarecrow. Although Zsaaz is clearly more of an antagonist to Rachel Dawes, WE the audience are meant to see him as an obvious criminal who is circumventing the system through Crane. Zsaaz is an obvious and more physical embodiment of Gotham's corruption. Crane is quickly shown to be working with none other than mob boss Carmine Falcone, and it is teased during that scene that the two are working for a higher authority. Extending into the corrupt city official department is the introduction to Jim Gordon's partner, the disgusting [Arnold] Flass, who is also quickly revealed to be working for Falcone.

Count em: 1) Joe Chill, 2) Carmine Falcone, 3) Ra's al Ghul (decoy), 4) Mr Zsaaz, 5) Scarecrow, 6) Flass, and last but certainly not LEAST 7) the real Ra's al Ghul.

Every one of these gets their "takedown", they all contribute to the story, and they all mean something to Batman. All in the span of 2 hours and 21 minutes.

Execution is the key.
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We don't know nearly enough about TASM 2 to make that assessment here. However, I think it would be cool if there was a "Russian Department" (although that might come off as a bit harmful) of supervillains Rhino, Kraven, and the Chameleon. I believe that IF Rhino is indeed in the movie (and it's all-but-confirmed), he'll be more of a mech than a man in an giant suit, and I think it would be interesting if Alexsei Sytsevich was a leg amputee.

Time will tell as always.

I'm more concerned about Webb's direction and the producers brilliant ideas.

The Lizard basically had the same origin as Green Goblin and was a run of the mill villain. Instead of being a parallel to Peter's transformation and tragic figure whose good intentions result in something bad they made him just turn evil after the dose - screw his arm or being against dosing veterans against their will.

On top of that there was the failure to juggle the supporting cast which only consisted of Captain Stacy, Gwen, Flash, Ben and May Parker.

I'm hoping for a major improvement in the sequel

Rhino should be in a fight sequence with Spiderman within the opening five minutes of ASM2 and nothing more. Perhaps a team-up with Electro