This cast is based on the lesson of the Dark Knight and the Green Lantern: GO DARK OR FLOP HUGE.
I had to drop all of my first choices on account of the CBM code of conduct, but I think this toned-down version is pretty good:  
SUPERMAN/CLARK KENT
Manson is like Christian Bale... on BEER.  He is a prodigy at incoherent mumbling and whispering.  Bat who?
PERRY WHITE
A newspaper editor needs to sweat profusely and have a bit of a hot temper. OJ can nail that.  
LOIS LANE
Some might find this choice a bit too dark.  But remember Kryptonian/Human pairings cannot produce offspring.  Ideal situation for Andrea.
LEX LUTHOR
Ok, this is casting against type, but just imagine... Jesus represents goodness and everyone trusts him and BAM -- he turns out to be your worst enemy.  Spine-tingling stuff.  
LEX LUTHOR'S HENCHMEN
For henchmen, unpredictable is good and these guys crank up the crazy.  Toasty was the first boss I ever encountered. I was SO scared to go in there.  Still gives me goosebumps.