Hey U Guys have posted the following excerpts from a roundtable interview with the actor and below are the relevent parts regarding The Amazing Spider-Man where Sheen reveals some new details about the relationship between Uncle Ben and his nephew as well as his thoughts on Andrew Garfield and the filming of the scene where Uncle Ben meets his make at the hands of an armed robber.

"I’m not in any of the scenes where he’s Spider-man. He’s still a little boy. He’s a teenager when it starts. I’m a surrogate father really, I’m his uncle. And so all of our scenes are just like you and I talking now. I’m dealing with this adolescent who is having problems with changes, with hormones changing and his getting out of hand. I have to give him the marching orders and so forth. It’s all very normal. And the guy playing him is wonderful..."
"He [Andrew Garfield] called me up and said he’d like to meet me and I said who are you and he said I’m playing your nephew. I said, you’re Spider-man! And we met for lunch and he was delightful. He just wanted to see who I was and whether I was open to changes, whether he could improvise with me. I was delighted and we had a wonderful time."
"I’ve never seen him in the uniform, I’ve never seen any of the stunts, any of the special effects, the green stuff. All my stuff is like normal acting and I don’t do anything with him otherwise. I’m dead in reel one y’know. I don’t do the end until I’m in New York. In April and May, that when I finish up with him. That’s where I get shot. There’s no special effects for me, that’s for the other characters."
If you'd like to read more about the actors other projects, follow the link below to head on over to the site. While any Spider-Man fan knows that Uncle Ben is killed before Peter becomes a costumed hero, I guess this pretty much confirms that we're going to see a full blown origin story. Of course, that really shouldn't be too much of a surprise considering that it will have been a decade since the release of the first Spider-Man movie by the time that this is released.
With an all star cast that includes Andrew Garfield as Spider-Man, Emma Stone as Gwen Stacy, Denis Leary as Captain George Stacy, Rhys Ifans as Curt Connors, Martin Sheen as Uncle Ben and Sally Field as Aunt May,
The Amazing Spider-Man is set to be released in 3D on July 3, 2012!