Collider was on the set of X-Men: Apocalypse and they learned how the X-Men universe has forever changed, following the timeline machinations of Days of Future Past. In this new timeline, the events of 2000's X-Men and all of its subsequent films (including the solo Wolverine films) are no longer canon.
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The world that exists in Apocalypse differs from the other X-Men movies in that in this timeline, mutants were exposed to the world in 1973 during the debacle at the White House, and so they’re living out in the open and mostly accepted.
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This new timeline is not necessarily leading towards the first X-Men movie anymore, although the philosophy is that the river will mostly end up in the same place with a few divergences here and there. This timeline is leading up to the New Future seen at the end of Days of Future Past, barring any other time travel changes.
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In this new timeline, people could die that were alive in X-Men 1, 2 and 3, and people could survive who died in those three films.
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Since the mutants aren’t in hiding anymore, this Charles Xavier’s School for the Gifted is a much bigger school and a “brighter, happier place” at the beginning of the film.
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The other Fox comic book adaptations Deadpool, Gambit, Fantastic Four and Wolverine take place in a post-Days of Future Past, post-Apocalypse The stadium dropping on the White House in 1973 is a key piece of their history.
Following the critically acclaimed global smash hit X-Men: Days of Future Past, director Bryan Singer returns with X-MEN: APOCALYPSE. Since the dawn of civilization, he was worshipped as a god. Apocalypse, the first and most powerful mutant from Marvel’s X-Men universe, amassed the powers of many other mutants, becoming immortal and invincible. Upon awakening after thousands of years, he is disillusioned with the world as he finds it and recruits a team of powerful mutants, including a disheartened Magneto (Michael Fassbender), to cleanse mankind and create a new world order, over which he will reign. As the fate of the Earth hangs in the balance, Raven (Jennifer Lawrence) with the help of Professor X (James McAvoy) must lead a team of young X-Men to stop their greatest nemesis and save mankind from complete destruction. In Theaters - May 27, 2016.
Cast: James McAvoy, Michael Fassbender, Jennifer Lawrence, Oscar Isaac, Nicholas Hoult, Rose Byrne, Tye Sheridan, Sophie Turner, Olivia Munn, Lucas Till, Evan Peters, Kodi Smit-McPhee, Alexandra Shipp, Josh Helman, Lana Condor, Ben Hardy