With Kraven as the last confirmed Sony movie, renewed popularity in Andrew Garfield's Spider-Man following No Way Home, and a new Spider-Man movie on the horizon, Sony could bring its villains over to the universe of The Amazing Spider-Man movies. This opens the door for them to appear either in brief cameos or as central antagonists. Either way, this is just one outline (inspired by the Spider-Man games) for how Kraven, Venom, Morbius, and others can be used in a Spider-Man movie. Another outline could be adaptaing the Clone Saga, but wouldn't feature these villains.
To make this work, a few assumptions are made. The universes from the recent Sony Marvel movies and The Amazing Spider-Man movies merged. This is also the universe where Knull chooses to reside in. He does so after he acquired and deciphered a partial Codex when Venom merged with the Xenophages in Venom: The Last Dance, and used it to break free. Meanwhile, the amazing Spider-Man has acquired a piece of the Symbiote that arrived on his Earth at the end of No Way Home, and already has had run-ins with Mr. Negative and his Inner Demons, setting the stage for this movie.
Act 1: Kraven's Last Hunt
Spider-Man responds to an Inner Demons attack, which leaves many casualties. Spider-Man, manages to fend of their leader Mr. Negative and helps the casualties, including Flash Thomspon, to FEAST, despite the Symbiote telling him to go after Mr. Negative. At FEAST, Spider-Man meets Dr. Michaels and nurse Rio Morales, who tend to the injured. Afterwards, Spider-Man is approached by Madame Web, who warns him that something is coming for the Symbiote. The Symbiote reasons it might be connected to Mr. Negative, so they decide taking out Mr. Negative should remain the priority.
Soon after, Spider-Man is ambushed by Kraven, who reveals the Venomized Spider-Man is his final prize. Kraven manages to shoot Spider-Man, and buries him. Spider-Man reawakens at night, digs his way out and makes his way to FEAST. There he is helped by her neighbour Rio's son Miles, who calls in the Night Doctor. The Night Doctor, who turns out to be Dr. Michael Morbius, uses electric shocks and his sonar abilities to sever the Symbiote’s bond with Spider-Man, allowing Spider-Man to heal. The Symbiote is untethered from Spider-Man, but scurries off to the next room.
Act 2: Agent Venom
Having recovered days later, Peter creates a new suit with Doctor Octavius, telling him the suit is "for a friend." During Spider-Man's abscence however, a new vigilante named Agent Venom has started taking on the Inner Demons. With the help of Eddie Brock, Spider-Man finds Agent Venom interrogating Kraven on how to track Mr. Negative. Spider-Man's arrival results in three-way fight, with Agent Venom ultimately defeating Kraven, but escaping in the process. Kraven allows himself to be arrested, having already proven before he can beat Spider-Man.
Spider-Man contacts Eddie Brock again, who reveals he is looking into the Symbiote himself. Arriving at Mister Negative's last whereabouts, Spider-Man finds Agent Venom having beat him to the punch. It's revealed Venom bonded with Flash as he shared a hatred towards Mr. Negative. Another three-way fight erupts, in which Mr. Negative is beaten and returned to his human form: FEAST's founder Martin Li. Having beat Mr. Negative, Spider-Man convinces Flash to let go of Li. Li, guilt-ridden, then transfers his powers to Venom to purify it into Anti-Venom.
Act 3: King in Black
Li reveals once Knull gave him access to Darkforce energy and corrupted him into becoming Mr. Negative, he developed an innate hatred towards symbiotes and it's wielders. Due to some unforeseen circumstance, Li also gained acces to Lightforce energy. Transformed, he used these powers to establish the Inner Demons to draw out the Symbiote-wielding Spider-Man. At this point, Eddie Brock, arrives and Anti-Venom bonds with him, resulting in Anti-Venom regaining his memories from Venom with Eddie Brock. However, Knull locates them due to this bond.
Knull's arrival is met by Spider-Man and Anti-Venom's opposition. When Flash shows up and manages to distract Knull, Anti-Venom is possessed by the Enigma Force and becomes Knull's antithesis. Like matter and anti-matter, the Enigma Force and Knull annihilate each other, ending the fight. Later, it's revealed both Miles and Dr. Morbius were infected with Spider-Man's blood. As result of the electric shocks, it triggered powers in Miles and cured Michaels' disease. In the end, Octavius deduces Peter is Spider-Man, but decides not to act on it yet.