io9:.."With comic book films being so huge right now in Hollywood and big-name actors like Robert Downey Jr. starring in films such as Iron Man, would you ever consider doing a comic book adaptation or a superhero film?"
Cusack.."I don't know, but yeah, for sure. I think the adult comics are some of the best film ideas out there."
"Are there any comics in particular out there that you'd like to make?"
"Not one that I particularly know that I would like to do, but whenever I've come across one, I've really liked them."
"Are there any [comic book movies] you've seen floating around in Hollywood that you'd like to see made?"
"Yeah, I can, there was one or two that I heard of that sounded really cool. One of them was about, I think... it's a vampire and a killer, and they're on the road, and it's this really strange story. I thought that sounded pretty cool. Also some of the obscure ones, I don't know if there are any more superheroes left."
"That sounds a little bit like Preacher?"
"I think it might have been Preacher."
"You should get involved with that!"
"I'm trying to. I heard about that one, I like that."
"Who would you want to play?"
"I'd say either the vampire or the priest. One of those two guys."
"So just the two best characters in the comic?"
"Why not?"
So, he's trying to get involved! Could Mr Cusack be being deliberately coy about this? Could he have even met with Sam Mendes about a role in the movie? Probably not judging by this..but, ya never know. Personally, although I'm a huge fan of Cusack, his name wouldn't be the first one that pops into my head when I think of an actor to play Jesse Custer..and certainly not Cassidy! But, he is a great actor so who knows.