According to Deadline Otto will play the main character, Nina Locke. Apparently the actress was heavily pursued to do pilots and fielded several offers before opting to do Locke & Key. The new Fox drama will be produced by Alex Kurtzman and Roberto Orci. The pilot was written by Josh Friedman(The Sarah Connor Chronicles)
For those unfamiliar with the comic, here's a synopsis..
It tells the story of Nina Locke and her three children, Tyler, Kinsey, and Bode, who survive an unspeakable horror and attempt to rebuild their lives at Keyhouse, their family home in Lovecraft, Massachusetts. It is a mysterious New England mansion, with fantastic and transformative keys hidden inside its walls that are also being sought by a hate-filled and relentless creature with ties to the Locke family’s past who will stop at nothing to accomplish his sinister goals.