According to
Deadline Pirates of the Caribbean: The Curse of the Black Pearl star Keira Knightley,
Like Crazy's Felicity Jones, and
Lost's Evangeline Lilly are up for the role of Dr. Cathy Muller Ryan. Keira Knightley is said to be the top choice to be paired up with Chris Pine. He is set to take on a role that has been previously played by Harrison Ford, Alec Baldwin, and Ben Affleck.
Another piece of information is that
Total Recall's dynamic duo Kate Beckinsale and Jessica Biel were both considered, but didn't make the cream of the crop.