Appearing on BBC Radio 1 to promote Spider-Man: Homecoming, Peter Parker actor Tom Holland gave his pick for who'd he like to see play Uncle Ben opposite Marisa Tomei's Aunt May. "I kinda want Tobey Maguire to play Uncle Ben, I think that’d be super funny, but I don’t think he’ll do it."
Maguire was actually a name many comic book fans picked for the role back when Marvel and Sony first announced Homecoming. Regardless of whether the fan suggestions reached Holland's ears or he picked Maguire on his own, it's an excellent pick. But it's currently unknown whether this new interpretation of Spider-Man lore will ever do more than allude to Uncle Ben's presence as he was entirely absent from Homecoming.
Should Marvel and Sony's Spider-Man trilogy ever wish to dive into Peter's backstory with Uncle Ben, one has to think Kevin Feige has at least reached out to Maguire or his reps, given how attuned the Marvel Studios President is with what fans want to see.