Other Villains
Nathan Jones or Glenn Jacobs for Rhino
Incase Marvel doesn't have the Sinister Six set up for next year's Spider-Man reboot, then Rhino along with Scorpion and Shocker should appear as villains of the Sinister Six in the sequel to the reboot and with either Nathan Jones or Glenn Jacobs cast as the character, Marvel is to have the actor portraying Rhino in his rock solid rhino costume form and not the mech suit version from Amazing Spider-Man 2
Christoph Waltz for Vulture
A villain who uses Tech Flight Gear and operates as a member of the Sinister Six
Colton Hayes for Eddie Brock/Venom
An ex boyfriend of Gwen Stacy turned enemy of Spider-Man by bonding with a black alien symbiote
Matt Letscher for Cletus Cassidy/Carnage
A psychopathe who bonds with a red alien symbiote spawned from the Venom symbiote who uses its abilities to wreck chaos and destruction
Julian Sands for Rodrick Kingsley/Hobgoblin
A goblin costumed supervillain who carries weapons and explosives and rides on a glider to terrorize New York City
Ryan Robbins for Amber Jenkins/Beetle
A member of the MCU's Sinister Six who wears a beetle themed armor that operates with a jetpack and deadly firepower
Seth Rogan for Egghead
A scientist and enemy of Ant Man
Kamar de los Reyes for Ghost
An expert spy and assassin who in the Marvel Cinematic Universe will serve as the Mandarin's second in command of the Ten Rings and as the secondary antagonist in Iron Man 4
Robert Maillet for Mangog
A powerful enemy of Odin and the recommended main antagonist for the fourth Thor movie
Viggo Mortenson for Norman Osborn/Green Goblin
Father of Harry Osborn and arch enemy of Spider-Man who would act as the main villain for the third MCU Spider-Man film
Kate Beckensale as Verna
Morlun's sister who will act as one of the villains for the yet to be confirmed Scarlet Witch film
Jason Clarke for Grim Reaper
A villain that uses a Scythe and the brother of Simon Williams
Will Ferrell or Guy Pearce as Modok
A cyber organic villain that can mentally control technology who should serve as the primary antagonist for the Black Widow spin off but whether he will be George Tarleton or Aldrich Killian reincarnated is yet to be decided
Ultimo
A giant robotic supervillain who will appear in Iron Man 4 as the Mandarin's ultimate weapon on wiping out all remaining HYDRA cells who is also capable of transforming into a helicarrier packed with plenty of firepower
Kim Kardashian or Shivani Ghai as Sunset Bain
An attractive women and chairman of her own company who provides services to the Mandarin
Patrick Dempsey as Doc Ock
An enemy of Spider-Man with 4 mechanical arms and leader of the Sinister Six
Michael Shannon for Lasher
A villain bonded with a green symbiote spawned from Venom
Arnold Vosloo as Dormammu
A faltine sealed away in the dark dimension who will act as the villain for the Dr Strange sequel
Other Characters
Ben Kingsley as Trevor Slattery
A british actor that Tony mistook for his arch enemy who turns out to have been an innocent man used by Firebrand as his scapegoat who was later taken by the Ten Rings under the request of the real Mandarin Zhang Tong to get him to understand everything that's going on as well as being taken prisoner
Gweneth Paltrow for Pepper Potts
Tony's assistant and current love interest
Mark Wahlberg for Arno Stark
Tony's long lost brother who will assist him on his battle with the Mandarin and the Ten Rings with an armor carrying plenty of armory
Zedaya as Michele
A supporting character in the Spider-Man films who is yet to be confirmed as Michele Gonzales
Ashley Greene for Spider-Gwen
Unlike the comics, Gwen will be depicted as Peter's older adopted Sister who will eventually gain her powers either from the second or third MCU Spider=Man movie and help him take down some new threats as Spider-Gwen
Nat Wolfe for Harry Osborn
One of Peter's best friends from school
Cara Delevinge for Liz Allen
A friend of Peter's and Harry Osborn's girlfriend
Bella Thorne or Hailey Clauson for Mary Jane Watson
Peter's girlfriend
James C. Burns for J. Johna Jameson
Editor and boss of the Daily Bugle who envy's Spider-Man
Keith David or David Ramsey for Robbie Robertson
A reporter at the Daily Bugle who knows that Spider-Man is a hero
Zac Efron as Ned Lees
a reporter of the daily bugle
Emily Ratajkowski as Betty Brant
An employee at the daily bugle
Zacheri Levi as Fandral
Ray Stevenson as Volstagg
Jamie Alexander as Lady Sif
Anthony Hopkins as Odin
Tadanobu Asano as Hogan
Natalie Portman as Jane Foster
Kat Dennings as Darcy
Johnathan Howard as Ian
Italia Ricci as Bethany Cabe
An agent of SHIELD who is expected to appear as a possible new love interest to Tony Stark who will assist him on taking on the real Mandarin, the Ten Rings, and Crimson Dynamo
Margot Robbie for Black Cat
A skilled burgalar who also has a crush on Spider-Man and helps him fight against some of his enemies
Rick Cosnett for Stan Carter
A cop of the NYPD
Shantel Vantensen for Jean Dewolfe
A cop of the NYPD
Benito Martinez as Quetzalcoatl
As an alternate version of the sun god, Quetzalcoatl will be depicted as a Makulan dragon who took Human form ruling and inspiring civilizations throughout history towards the end of the Middle Ages as the original Mandarin before Zhang Tong
Selena Gomez as Sasha
daughter of the Mandarin Zhang Tong
Morena Baccarin as Rosalyn (Zhang Tong's Wife)
Wife of the Mandarin (Zhang) who was the daughter of a South american drug lord assassinated by the Winter Soldier but was escorted safely out of Mexico by Zhang as the Mandarin who marries her a year later and is currently a hotel manager in Orlando Florida
Oscar Issac as Rosalyn's brother
Brother of the Mandarin's wife and current head of his father's drug cartel
Jasmine Villegas or Becky G for Ava Ayala/White Tiger
A member of the New Avengers trained alongside Spider-Man and by Black Panther
Well to find out if any of the characters in this article will be used for the Phase 4 films stay tuned for more updates yet to come.