This was after the 'Disassembled' storyline. Right after Bendis made one of the biggest changes in the Marvel Universe. But he did not stop there! No, he continued in the comic 'Secret War' which would continue to reshape the Marvel Universe in ways we could not have imagined! And here is my take on it.
Nick Fury, Director of SHIELD- Samuel L. Jackson
Steve Rogers/Captain America- Trevor Donovan
Natasha Romanoff/Black Widow- Scarlett Johannsen
Peter Parker/Spider-man- Jake Gyllenhall
Matthew Murdock/Daredevil- Michael C. Hall
James "Logan" Howlett/Wolverine- Hugh Jackman OR Christian Kane
Luke Cage- Terry Crews
Jessica Jones- Kate Beckinsale
Henry "Hank" McCoy/Beast- Kelsey Grammer
Scott Summers/Cyclops- James Marsden
Emma Frost- Joleen Blalock
Katherine "Kitty" Pryde/Shadowcat- Ellen Page
Reed Richards/Mister Fantastic- Billy Crudup
Susan Storm Richards/Invisible Woman- Diane Kruger
Johnny Storm/Human Torch- Chris Evans
Benjamin Grimm/The Thing- Michael Chiklis
Maria Hill- Hilary Swank
Daisy Johnson- Eliza Dushku
James Woo- Collin Chou
Jasper Sitwell- Luke Ford
Simon Maddicks/Killer Shrike- Paul Walker
Phineas Mason/Tinkerer- Jackie Earle Haley
Frank Payne/Constricor- Vin Diesel
William Cross/Crossfire- Josh Lucas
Deborah "Debbie" Bertrand/Diamondback- Claire Forlani
Jason Macendale/Jack O'Lantern- Clive Owen
Carolyn Trainer/Lady Octopus- ?????
Steven Hudak/Scorcher- Tyrese Gibson
Macdonald "Mac" Gargan/Scorpion- Timothy Olyphant
Herman Schultz/Shocker- Dominic Purcell
And last but certainly the Big Bad of this series:
Lucia Von Bardas- Eva Green
Some of these characters I have had trouble casting and would greatly appreciate your input on who should portray them on screen.
And that's my cast!