The most obvious thing that Joss and company could make would be agents of SHIELD doing their daily job, and from time to time have minor heroes show up here and there. Some may consider that boring to some, but to me it sounds good. I don't know about you guys but I don't want to much interference with the movies. Nothing that could affect any of the upcoming films (IM3, TTDW, CATWS, GOTG, etc.). What would be awesome is if characters like Steve Rodgers and his teammates had camoes in the show. Also, Agent Sitwell should be one of the main characters/agents.
-Pilot-
Agent Sitwell is sitting in a chair, talking into an earpiece.
"Of course sir. Yes, I do realize. Yes, I agree. Thank you for giving me this opportunity Director Fury. I'll see you in New York."
Sitwell stands up from the chair, and the camera pans to reveal the interior of a quinjet. He tells the pilot to redirect the path and head to NY. This will be the introduction of Daredevil, although he won't fully appear until after a few episodes. The quinjet scene transitions to a jungle, then zooms out to reveal that someone is standing there. We see the foot walking, and the camera follows. It zooms up to reveal the person dressed in hunter-esque clothing. He has a knife and is cutting through leaves, then all of a sudden a dark figure tackles him out of the frame. It is later revealed that the hunter was in Wakaknda and the figure that tackled him is Black Panther. The end of the pilot shows Sitwell talking to someone, then when he finishes speaking, the person replies and it is obvious that it is Samuel L. Jackson.
These are a few ideas on how to start the series, by introducing the characters and settings. Let me know in the comments below what you think of this and give me some of your thoughts on what you would want to see!