Since the movie is happening, here are three things I think should happen.
1. Introduce a bunch of villains. I don't mean Spidey should battle the Sinister 6, I mean introduce the human side of some well-known villains. I'm sure they will show Osborn Industries. Perhaps they can have Dr. Otto Octavius working for Norman Osborn, have Eddie Brock appear as a classmate, (similar to the Spectacular Spider-Man), and have of course, cameos. Such as a billboard with Kraven on it.
2. Make Spider-Man tell jokes in the middle of a fight. The one thing a lot of people didn't like in the Spider-Man trilogy was that Spider-Man wasn't the wisecracker he is. I'm sure they'll fix that in the reboot.
3. Make sure Aunt May is not Ultimate. I know the movie will be based on Ultimate, but I hope they don't do exact details. I can't see many people liking the Ultimate version of Aunt May.
And those are three things that I think should happen in the Spider-Man Reboot.