Let me preface this article by saying I was extraordinarily against what I have been hearing, but I gave it a lot of thought and my opinion has changed. It has become evident that Peter Parker's origin as Spider-Man will be Ang Lee'd in the sense that Richard, Peter's father, will put something in Peter's DNA that enables him to become Spider-Man.
When I first heard about this, I was bummed and borderline angry. The appealing part of Peter Parker was that he was average guy and just happened to gain these powers by accident. It also made me worry about how Uncle Ben would be treated if it was Peter's cinematic destiny to become Spider-Man. However, hear me out...
For one, this actually gave me a sense of relief that we wouldn't just be seeing another Spider-Man origin that would, at the center of it all, strongly resemble Sam Raimi's origin from Spider-Man 1. While it does stray from the source material, at least it will be a new and fresh take on the character. While a new interpretation of what Raimi did might be interesting for comparing and contrasting, it'd get a little stale and there would definitely be a sense of, "I've already seen this". While this will be a nice change of pace, it means little in the grand scheme of things. Let's move on to the more important details...
Does this change Peter Parker or Spider-Man as a character at all? I mean, honestly, not really. When I think of Peter Parker, I actually rarely consider the circumstances surrounding his origin as a superhuman as part of what makes him great. His humanity, awkwardness, and his ability to discern responsible vs. irresponsible are. If this power lies dormant within him, and it's awakened with this spider bite? The idea, in and of itself, is actually one that could prove to be extremely fruitful in the progression and development of the character in this universe.
It seems as though Peter's father will be working on this revolutionary project, that he desperately wants to use for good. However, he's worried it will get in the hands of the wrong people (cough Norman Osborn cough). I think his father, knowing he's in a dead-end of a predicament, will instill what he's developed into Peter to keep the project hidden, but alive. Peter's eventual transformation into Spider-Man and doing good and upholding the wellbeing of people was what his father dreamed of. It's actually brilliant storytelling.
Naturally, this brings up caution of the treatment of Uncle Ben. But will his importance in the origin story really be abused or ignored? I don't think so. Yes, Peter's father hides this power within him, but who is there to teach him how to harness it and use it for good? Richard isn't, but Ben is. Just because Peter's father gives him this power, does not mean Peter will know how to use it, and that's where Uncle Ben's cruciality has always lied. In essence, Richard gives Peter his powers, but Uncle Ben gives Peter his moral compass and his constant desire to do good.