The Villains for Spider-Man is Equally important as the hero. When it comes to who you are going to pick for the villains. Well i've got an idea though a lot of pepole will dissagre with bring back Green Goblin back...well actualy he is not the Green Goblin really in this one. I will explain more as i go along.
The main villain of the film is Norman Osborn Sr. He is different from Normal Osborn in the Comics but also similar. Normal Osborn is extremely arrogant and has an obession with perfection. This is why he erases any crimes leading back to Oscorp and devlops the Spiders and the Goblin Seurm to become perfect. He has a son named Norman Osborn. Intrested in Spider-Man due to the fact he displays supernatural abilties he asks his top hit-man nicknamed the Vulture to go after Spider-Man. He devlops the Goblin Formula but the seurm was not devloped enough and turned him into the Goblin (The Ultimate Spider-Man Version). He is betrayed by Norman as he helps Spider-Man take down his father and both the Vulture and the Goblin end up going to prision. In the end credits scene Normal Osborn Jr admits that he spiked the Golbin Formula so it would be imperfect he would turn into the Goblin and get arrested.
Norman Osborn Jr is not the villain in the Spider-Man Reboot. While he does have a lot of similar trates to his father he is not the same as they have a different veiw on how they should carry out their actions unlike his father Norman Osborn Jr who always displays a hard and cold attitude, Norman Osborn Jr seems to be a much more sociable person than his father and displays some kindness. However, this is a ruse as shown during the after scene of the film. He is ruthless when it comes to finding perfection like his father but unlike his father. He is much more cunning as shown as he lays his plans for Spider-Man to defeat the Goblin and the Vulture so he can own his father's company and use it for Project Dark Reign. It is revealed that Norman is secretly the main driving force for the Civil War and is the winner in the movie as the Goverment now trust him over Tony which leads him to form HAMMER. Spider-Man is orginally on Tony's side but due to Norman's actions switches sides. He also has an allience with Thanos.
The Secondary Villain of the film is the Vulture. Normal Osborn Sr has aquired the technology used for Falcon's suit and decided to use it in order to make his top hit-man and asssassin Adrain Tooms even more deadly . He joins Oscorp after he murders Gregory Bestman. He is Norman Osborn Sr's greatest ally and the one one he trusts. He attacks Spider-Man several times through out the film and along with the Goblin fight him in the final battle. He is the villain that spends the most screen time fighting Spider-Man. He is eventually defeated and put into prision along with Normal Osborn Sr.