Marisa Tomei has previously said that she was pitched a slightly different arc for May Parker when she initially signed on to play the character in Captain America: Civil War, and the Academy Award-winner has now revealed that she'd be open to reprising the role at some point.
Spoilers for Spider-Man: No Way Home follow.
Of course, Peter Parker's beloved Aunt was killed-off in No Way Home after an encounter with The Green Goblin, but the introduction of the Multiverse means Tomei could still play a May Variant.
“Oh yes, there is a Multiverse," responded Tomei when asked about May's demise and possible return by Jimmy Fallon. "That was part of the secrecy originally, now a lot of people know. But the thing was, if anyone asked me about it, I don’t understand the Multiverse myself. Our wonderful director, Jon, and I’m like ‘And so, where am I now? Ok, well, can you explain it to me one more time?’"
"I would love to come back and be a part of that," she continued. "There’s history there, too. May Parker hooks up with Ant-Man. Well, I mean, she’s a standalone character, of course, but there are more avenues to explore."
May was basically subbed-in for Peter Uncle Ben in the recent threequel, laying the "with great power comes great responsibility" speech on her nephew right before she passed. For this reason, bringing the character back in any capacity might not sit very well with fans. That said, Sony Pictures was reportedly considering an Aunt May solo movie at one point, so you never know!
Would you like to see Marisa Tomei return as May Parker? Check out the full interview in the video below.