The Lizard
Well Dr Conner has been in spider-man movies for a while.It is aobut time he change into a big reptile and eat people
kingpin
The best gang lord to have in a superhero movie,id kingpin to make spider-man crime life difficult
Would it be awsome if the kingpin with the help of science revive doc ock so the next movie he will form the sinister six
Blackcat
There are many womens in peter parkers life now:Aunt May,Mary Jane,Betty Brent,Gwen Stacy,but ther should be a lady who can spice some thins up in spiderman life
Kraven the hunter
karven will be sent to hunt spidr-man down by kingpin,so kingpin can have an apprintice killer,just like bulleye in daredevil
Chameleon
With chameleon mask skills he can spy on spider-man to find out his true identity and also work with the kingpin