At the 2010 San Diego Comic-Con International, Anderson and Jeremy Bolt told ShockTilYouDrop.com that a fifth Resident Evil film would be possible.
"We always take it one movie at a time. We put so much effort into them and it is a family affair. It is all about making the best possible movie now and then promoting well and getting it out there. Making sure it is seen in the right way. When the dust settles then you think about something else. For us, it is not a business, it is a passion. You don't want to start talking about the next baby until you make sure this one is okay."
Anderson later told IGN that if the film is a success, he will do the fifth film. He would like Leon Kennedy to make an appearance and Jill Valentine to be the villain under control by umbrella. Well there you have it. What do you think box office flop or box office success?