Thanks to BuddyTV I was able to find out what the highlights of the Supernatural panel were:
-At the panel they showed a video preview of the fourth episode, "Weekend at Bobby's," directed by Jensen Ackles. The episode will focus on Bobby trying to get out of the deal he made with Crowley to give away his soul at the end of season 5.
-Though Eric Kripke's five-year plan is over, he sees season 6 as a sequel to his Supernatural.
-New showrunner Sera Gamble talked about the driving mythology of season 6 being based on the monsters of the week. We'll see more monsters and their backstories will play into the new season. The show will also get back to simpler things, like shooting monsters in the face.
-How did Sam get out of Hell? "Practice," joked Jared Padalecki, stealing the old line about Carnegie Hall. But in reality, he still doesn't know.
-Dean won't be kissing demons anytime soon. However, Sam and Dean will have some lady drama in an episode featuring a female relative of the Winchesters.
-Misha Collins said that Castiel is still busy cleaning up Heaven in season 6.
-Jim Beaver believes that Hell will freeze over before Bobby gets a girlfriend, so don't hold your breath.
-Ben Edlund is writing an episode about fairies that will feature little people.
-Jensen Ackles revealed that the hardest part of directing was having to pay attention to every single line of dialogue in the script and not just worry about his own character. Jim joked around about wanting to give Jensen a hard time by considering staying in his trailer for 30 minutes after being called to set.
-Everyone would love for Jeffrey Dean Morgan to return, but unfortunately he has a very busy schedule.
-Eric Kripke said that he made some changes to the season 5 finale due to the show coming back, but it mostly stayed the same. He said that if it wasn't renewed, major characters probably would've stayed dead.
Zap2It were able to find out a little about where Dean is at the beginning of the season as well as what one of the episodes will be about, here is the video below.