Before you all have a heart attack I want to aware you that I would not, in any respects, want Marvel to get the rights back to Deadpool. Granted they represent their characters with a lot more decency (with the exception of The Mandarin and Malekith) and respect than Fox, that goes without saying, but I would like to see where Tim Miller and his team go with his story arc in that universe.
Now, onto pressing matters...
The image above describes a series of existing and established plot points that tend to carry through every phase in the Marvel Cinematic Universe. It shows all the way back from HYDRA to the Super Soldier serum to Extremis, ultimately leading up to The Merc with a Mouth himself. Looking back at this I should have instead put A.I.M instead of HYDRA seeing as we have no clue outside of quick dialog whether HYDRA still exists or if A.I.M is HYDRA. But set back, set back, interperut however you please. These elements I believe combined in the right respects could work and you wouldn't need to change much of anything else. The Super Soldier serum makes you faster and stronger, something a man dying of any form of cancer would need, and it wouldn't hurt to be able to heal or regenerate to overcome any illness or disease. And HYDRA loves their mercenaries, and would go to any lengths to create the ultimate soldier, perfected unlike the Red Skull and to prove quite the match for Captain America or any of The Avengers. Instead of Stryker, Killebrew, etc. creating him, why not have Baron Von Strucker? He is rumoured for a small role in The Avengers: Age of Ultron which is supposed to be carried over from Captain America: The Winter Soldier. Still keep Deadpool insane, talking to the voices in his head, breaking the fourth wall, classic Wade.
Well, there it is, folks. Please don't be to harsh, this was just something that I had a ton of fun with and chose to share it with all you here on CBM. God bless and happy holidays!