According to JudgeDreddMovieNews.com..
It hasn't been officially announced but Lena Headey has been cast as the main villian and gang-leader, Madeline Madrigal AKA Ma-Ma. Lena began work on the film last week.
Bleeding Cool also back up the casting. Headey is a fine actress, having already made her way into fanboy's hearts starring as the title character in
Terminator spinoff series
The Sarah Connor Chronicles and as Queen Gorgo in
300. But what about that character of Ma Ma Madrigal? Well, as far as I know she has never appeared in the comics but then she could be a newer character, I haven't read 200AD in a while! Any of you guys heard of her? I can't find any info online.
Anyway, in the script by Alex Garland she is described as
a woman in her late fifties or early sixties with a big scar through her cheek and lip. Lets assume they decided to go a little younger! What do you make of this? Interesting to have a female lead villain at any rate.