According to Live For Films, they have received an e-mail claiming that Christopher Nolan (director of Batman Begins & The Dark Knight, and the man that will be behind the eventual Superman reboot) has been talking with Billy Zane. They also say they received another e-mail (which according to them, is pretty reliable) saying the same thing. This is indeed interesting stuff, considering Nolan has no known plans to make any movies other then Batman 3 and Superman after Inception, so this could mean Zane may appear in either one of them.
Zane has a pretty significant likness to Lex Luthor, and no doubt could play it in a Nolan directed Superman. I assume this may be the role he is in contention for... however, do you have any idea who Zane could play in Batman 3?