For Batman and Birdman actor Michael Keaton, he is set to play the film's main antagonist who is heavily rumored and almost 100% confirmed to be Adrien Toomes aka the Vulture who is rumored to have crossed paths with Spider-Man before the events in Captain America Civil War Now for the other two actors confirmed as villains
Logan Marshall Greene is cast as one of the movie's secondary antagonists who could be either the Tinkerer, Scorpion, Shocker, Mysterio, or Beetle but certainly NOT as the younger version of the Vulture
Bokeem Woodbine is expected to play either the Tinkerer, Shocker, Mysterio, Beetle or Hobgoblin Now for the cast that is yet to be confirmed as major villains in this movie
Hannibal Buress has been cast as a hot dog vendor who is yet to become a villain later on hopefully later in this film and the one villain he would be suitable for is the Rhino as Alexander O'Hern
and Michael Mando, whose role is yet be confirm is rumored to play the villain Carnage
While Buress and Mando are yet to be confirmed as major villains for this movie, only 2 to 4 more actors are yet to be confirmed an casted so only then the movie will for the first time bring out the Sinister Six or just the 4 villains that were planned for the Scrapped Spider-Man 4 movie plus the Tinkerer but until then keep tabs on the updates and see how many more actors and actresses Marvel and Sony will cast for Spider-Man Homecoming