In this interview about her husband Mike Comrie, it mentions their having the script for "Spider-Man" with the role listed as "girl" for the love interest. Specifically in this part under the section titled Mr.Duff:
Although tastefully furnished (Comrie says he's unsure if anything is from The Brick), it is relatively humble by Beverly Hills standards. The kitchen contains evidence of their professional lives – his daily diet is posted on the fridge (from a bacon cheddar burrito for breakfast to five pigs-in-a-blanket as a nighttime snack) and a script marked “Spider-Man” sits on the table, with lines for a character simply called “girl” highlighted in yellow (rumors swirl about who Spidey's love interest will be in the series' next installment.)
Sweetre15: Also judging from Duff's looks I have a hunch that she's likely in contention for Gwen Stacy. Look at this pic:
Source: http://www.theglobeandmail.com/sports/hockey/mike-comrie-and-hilary-duff-beauty-and-the-brick/article1696250/