14 months after the Blacklight Runner Alex Mercer saved the Infected New York on his quest for redemption, Sgt. James Heller returns to the city, once his home, following his dismissal from a war in the Middle East. He discovers that his wife and daughter have been killed, sending him into a downward spiral of grief and rage. He heads out on a suicide mission into the heart of the Red Zone with the intention of dying in action and taking as many abominations as he can with him. However, before he is defeated by the creatures, Alex Mercer finds him. Taking pity on Heller, he infects him with his own strain of the Blacklight virus. He awakens with incredible powers, and discovers part of the truth; Alex Mercer was responsible for the outbreak that killed his family. Heller swears to use this second chance to exact his revenge on Alex Mercer, to avenge his family and city, and lay his own anger to rest.
Prototype 2 is set for a 2012 release date.